전남대학교 특용작물학실험실, Chonnam national university Special Crop Science Lab

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 > Lavandula species are rich in bioactive compounds, among which rosmarinic acid (RA) is a major phenolic known 
> for potent antioxidant and anti-inflammatory activities. In this study, Lavandin (Lavandula × intermedia), a sterile 
> hybrid widely cultivated for essential oil production, was used to develop RA-enriched cell extracts through 
> plant cell culture technology combined with methyl jasmonate (MJ) elicitation. Lavandin cell suspension cultures 
> accumulated higher levels of RA compared to those of L. angustifolia, and MJ treatment further enhanced RA 
> biosynthesis, as confirmed by the upregulation of RA biosynthetic genes. Extracts derived from untreated and MJ
> treated lavandin cell suspension cultures were assessed in LPS-stimulated RAW 264.7 macrophages. Both extracts 
> were non-cytotoxic and significantly suppressed nitric oxide production, pro-inflammatory cytokines (TNF-α, 
> IL-1β, IL-6), and the expression of iNOS and COX-2. Notably, the MJ-treated lavandin cell extract exhibited superior 
> anti-inflammatory efficacy. Mechanistic analyses revealed that lavandin cell extract selectively inhibited the IKK/
> IκB/NF-κB pathway with minimal influence on MAPK pathways, while concurrently activating the AMPK/Nrf2/
> HO-1 axis. These findings demonstrate that MJ-elicited lavandin cell extract enriched in RA possesses strong anti
> inflammatory activity and highlight its potential as a functional biomaterial for mitigating oxidative stress–related 
> and inflammatory conditions.
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“ Special Crop Science Lab ”

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